TABLE 4.

Univariate and Multivariable Analyses of Predictors of Post-LT HCC Recurrence

Predictor	HR (95% CI)	P Value
Univariate Analysis
AFP at LT group (ng/mL)
≤ 100 (vs. > 1,000)	0.14 (0.04-0.43)	0.001
101-499 (vs. > 1,000)	0.35 (0.14-0.86)	0.02
500-1,000 (vs. > 1,000)	0.18 (0.03-1.27)	0.09
Age (per year)	1.02 (0.99-1.05)	0.19
Female (vs. male)	0.75 (0.47-1.21)	0.24
Race/ethnicity
Asian (vs. Caucasian)	0.61 (0.31-1.17)	0.14
Hispanic (vs. Caucasian)	1.10 (0.61-1.96)	0.76
Black (vs. Caucasian)	0.66 (0.32-1.39)	0.27
Cause of liver disease
Hepatitis B (vs. hepatitis C)	0.51 (0.22-1.17)	0.11
Alcohol (vs. hepatitis C)	2.50 (1.24-5.03)	0.01
NASH (vs. hepatitis C)	0.49 (0.07-3.56)	0.48
Autoimmune (vs. hepatitis C)	0.29 (0.04-2.07)	0.22
MELD-Na Score (per point)
At listing	1.01 (0.97-1.05)	0.56
At LT	1.01 (0.98-1.04)	0.48
Child class
Child C at listing (vs. Child A)	1.39 (0.76-2.53)	0.29
Child B at listing (vs. Child A)	1.16 (0.73-1.82)	0.53
Child C at LT (vs. Child A)	1.67 (0.93-3.00)	0.09
Child B at LT (vs. Child A)	1.73 (1.02-2.95)	0.04
Radiographic tumor stage
UCSF down-staging (vs. Milan) (initial)	0.92 (0.40-2.11)	0.85
UCSF down-staging (vs. Milan) at LT	2.11 (1.06-4.20)	0.03
Radiographic tumor number (per additional lesion)
At listing	0.89 (0.66-1.21)	0.47
At LT	0.98 (0.74-1.30)	0.89
Received LRT	0.77 (0.51-1.17)	0.22
Time from initial HCC MELD exception to LT (per month)	0.92 (0.87-0.98)	0.005
DRI (per point)	1.32 (0.81-2.17)	0.27
Multivariable Analysis*
AFP at LT ≤ 100 ng/mL (vs. > 1,000 ng/mL)	0.14 (0.04-0.43)	0.001
AFP at LT 101-499 ng/mL (vs. > 1,000 ng/mL)	0.35 (0.14-0.86)	0.02

^*Variables removed by backward elimination: cause of liver disease (P = 0.06), UCSF down-staging vs. Milan at LT (P = 0.27), Child-Pugh class (P = 0.08), and time from initial exception to LT (P = 0.71).