Figure 2.

Testicular histology following radical orchidectomy for suspected malignancy in a subject with testicular rest cell tumour (TART) secondary to poorly controlled congenital adrenal hyperplasia due to CYP11A1 deficiency. Staining with haematoxylin and eosin (A and B) shows the nodules of TART. Inhibin staining (C) is positive for TART but also Leydig cells (LC), seminiferous tubules (ST), and lipid-laden cells (L-L C), believed to be adrenal rest cells. Staining with CD56 (D) shows uptake by some cells in the TART nodule and adrenal rest clumps (ARC) but not the Leydig cells or seminiferous tubules.