Table 3.
Examples of Immunosuppressive Products from Sponges
| Compound | Compound class | Species/order | Mode of action | Reference |
|---|---|---|---|---|
| Simplexides | Glycolipid | Plakortis simplex/Homosclerophorida | Inhibitor of T-cell proliferation | Costantino et al.,1999 |
| Polyoxygenated sterols | Sterol | Dysidea sp./Dendroceratida | IL-8 inhibitor | Leone et al., 2000 |
| Contignasterol | Oxygenated sterol | Petrosia contignata/Haplosclerida | Histamine release inhibitor | Takei et al., 1994; Bramley et al., 1995 |
| Xestobergsterols A and B | Pentacyclic sterol | Xestosponga berquistia/Haplosclerida | Histamine release inhibitor | Shoji et al., 1992 |
| Taurodispacamide A | Pyrrole-imidazole alkaloid | Agelas oroides/Agelasida | IL-2 inhibitor | Fattorusso and Taglialatela-Scafati, 2000 |
| Pateamine A | Thiazole macrolide | Mycale sp./Poecilosclerida | IL-2 inhibitor | Northcote et al., 1991 |