Table 1.
The effects of Brevinin peptides on pro-inflammatory and anti-inflammatory cytokines
| Peptide | Action | Cell source | References | |
|---|---|---|---|---|
| Pro-inflammatory | ||||
| TNF-α | Brevinin-2GUb/B2RP-ERa | Inhibit | ConA-stimulated PBMC | Popovic et al. (2012) |
| INF-γ | Brevinin-2GUb | Inhibit | Unstimulated PBMC | Popovic et al. (2012) |
| IL-1β | Brevinin-2R | Stimulate | A549/HepG2 | Homayouni-Tabrizi et al. (2015) |
| IL-6 | Brevinin-2R | Stimulate | HepG2 | Asoodeh et al. (2013) |
| IL-8 | Brevinin-2R | Stimulate | A549 | Homayouni-Tabrizi et al. (2016) |
| Anti-inflammatory | ||||
| TGF-β | B2RP-ERa | Stimulate | Both ConA-stimulated/unstimulated PBMC | Popovic et al. (2012) |
| IL-4 | B2RP-ERa | Stimulate | Both ConA-stimulated/unstimulated PBMC | Popovic et al. (2012) |
| IL-10 | B2RP-ERa | Stimulate | ConA-stimulated PBMC | Popovic et al. (2012) |