Table 3.

Genes predicted to be regulated by IRF1 and IRF7 as identified by IPA analysis in R848- and IFN-α treated PM cells

R848-induced cells		IFN-α-induced cells
IRF1 predicted to be activated (35 genes) (P = 2.23E−26)	IRF7 predicted to be activated (56 genes) (P = 1.26E−31)	IRF1 predicted to be activated (39 genes) (P = 3.23E−29)	IRF7 predicted to be activated (42 genes) (P = 4.44E−41)
CXCL1, CCL3, CCL2, CXCL5, S100A8, C3, CXCL3, TLR1, CXCL2, TLR2, CCL5, CXCL11, CCL4, CCL7, CXCL10, CASP4, MYD88, CHIL1, IL1B, ZC3H12A, TNIP1, IL1A, GBP5, OLR1, LYN, C4B, IL27, HCK, NLRP3, IFI202B, CCL12, CXCL13, CLEC7A, TNFAIP3, CD14	C3, CASP1, CASP4, CASP8, CCL2, CCL5, CCRL2, CD274, CD40, CD86, CMPK2, CXCL10, CXCL11, CXCL9, EIF2AK2, FAM26F, FCGR1A, FGL2, GBP2, GBP3, GBP5, GBP6, HERC6, ICAM1, IFI16, IFI35, IFI47, IFIT1, IFIT1B, IFIT2, IFITM3, IGTP, IL15, IL15RA, IL1R1, IL6, ISG15, KLRK1, MX1/MX2, OAS1, OASL, PTGS2, RSAD2, SLFN1, SLFN13, SLFN2, SLFN5, SP110, TAP1, TGTP1, TGTP2, TLR9, TNF, TNFSF10, TRAFD1, USP18	CASP1, CCL5, CCL7, CD14, CD40, CEBPB, CEBPD, CLIC4, CXCL10, DTX2, FCGR2, GBP5, GCH1, GFAP, IFI47, IKB, IL12B, IL1B, IRAK2, LCN2, LILRB4, NLRP3, NOS2, MAPK, PLSCR1, PRKAA, PSME2, SERCA, SLC16A10, SLFN2, SPATA13, SUSD6, TANK, TNFA, TNFAIP2, TNFAIP3, TNFSF15, TNIP1, TRIP10	APOBEC3, LY86, TLR2, TLR3, TLR7, TLR9, ISG20, NLRC5, NOD2, TMEM173, CASP4, MYD88, NOD1, OASL2, OASL1, MX1, MX2, LYN, BST2, IFI202B, OAS1B, RIPK2, OAS1A, RNF135, EIF2AK2, IFIH1, C3, CSF1, IFITM3, PML, KLRK1, OAS3, RSAD2, SP110, OAS2, NAIP6, IRGM1, TRIM25, AIM2, DDX58, IFIT3, TRIM56, IFIT2, IFIT1