Fig. 4.

Arthritis development in DA.DA/ZtmRhd-Cia11 congenic rats. (a) Disease incidence after PIA in DA.DA/ZtmRhd-Cia11 homozygous rats (DA/Ztm, n = 7), DA.DA/ZtmRhd-Cia11 heterozygous rats (Heterozygous, n = 13), and DA littermate controls (DA/OlaHsd, n = 15). Data from two independent experiments were pooled and shown as mean of arthritis incidence. (b) Arthritis severity is shown as mean ± SEM of clinical arthritis score. No significant difference between the groups was observed. (c) Arthritis incidence after CIA in DA.DA/ZtmRhd-Cia11 homozygous rats (DA/Ztm, n = 40), DA.DA/ZtmRhd-Cia11 heterozygous rats (Heterozygous, n = 29), and DA littermate controls (DA/OlaHsd, n = 27). Data from four independent experiments were pooled and shown as mean of arthritis incidence. (d) Mean arthritis severity after CIA. There was no significant difference between the groups