Table 1.
Cytotoxicity and Antiviral Activity of the Studied Compounds in Human Erythroleukemia Cells (HEL).
| Compound | MCC*, μM (μg/ml) | MIC50*2, μM (μg/ml) | ||||
|---|---|---|---|---|---|---|
| Simplex herpes 1 KOS virus | Simplex herpes 2 G virus | Cowpox virus | Vesicular stomatitis virus | Simplex herpes 1 TK-KOS ACVr virus | ||
| 3 | >300 (>100) | >300 (>100) | >300 (>100) | >300 (>100) | >300 (>100) | >300 (>100) |
| Umifenovir | 188 (100) | >37 (>20) | >37 (>20) | >37 (>20) | >37 (>20) | >37 (>20) |
| Brivudine | >250 | 0.04 | 183 | 50 | >250 | 2 |
| Cidofovir | >250 | 6 | 2 | 22 | >250 | 6 |
| Acyclovir | >250 | 0.2 | 0.08 | 250 | 250 | 2 |
| Ganciclovir | >100 | 0.08 | 0.03 | >100 | >100 | 0.2 |
*Minimum cytotoxic concentration of the compound leading to the appearance of morphological changes in the cells (detected microscopically).
*2Minimum inhibitory concentration of the compound needed for a 50% decrease in the cytopathic effects of the virus in the cell colony.