Table 3.
The genotype frequencies of MxA polymorphisms in uncomplicated patients and complicated patients
| SNPs and genotypes | Uncomplicated cases | Complicated cases | Crudea | Adjustedb | ||
|---|---|---|---|---|---|---|
| No. (%) | No. (%) | OR (95 % CI) | P value | OR (95 % CI) | P value | |
| Northern population | (n = 103) | (n = 150) | ||||
| C-123A | ||||||
| CC | 72 (71.3) | 125 (85.6) | Reference | Reference | ||
| CA | 26 (25.7) | 20 (13.7) | 0.44 (0.23–0.858) | 0.01 | 0.36 (0.17–0.78) | 0.01 |
| AA | 3 (3.0) | 1 (0.7) | 0.19 (0.02–1.88) | 0.15 | 0.28 (0.02–4.37) | 0.37 |
| CA + AA | 29 (28.7) | 21 (14.4) | 0.42 (0.22–0.79) | 0.006 | 0.36 (0.17–0.76) | 0.007 |
| G-88T | ||||||
| GG | 56 (55.5) | 97 (66.4) | Reference | Reference | ||
| GT | 35 (34.6) | 43 (29.4) | 0.71 (0.41–1.24) | 0.22 | 0.63 (0.33–1.22) | 0.17 |
| TT | 10 (9.9) | 6 (4.1) | 0.35 (0.12–1.00) | 0.06 | 0.51 (0.15–1.75) | 0.29 |
| GT + TT | 45 (44.5) | 49 (33.6) | 0.63 (0.37–1.06) | 0.08 | 0.61 (0.33–1.13) | 0.12 |
| Southern population | (n = 37) | (n = 151) | ||||
| C-123A | ||||||
| CC | 33 (89.2) | 118 (78.2) | Reference | Reference | ||
| CA | 4 (10.8) | 30 (19.9) | 2.10 (0.70–6.38) | 0.24 | 2.07 (0.68–6.31) | 0.20 |
| AA | 0 (0) | 3 (2.0) | NA | NA | NA | NA |
| CA + AA | 4 (10.8) | 33 (21.9) | 2.31 (0.76–6.98) | 0.17 | 2.30 (0.76–6.97) | 0.14 |
| G-88T | ||||||
| GG | 21 (56.8) | 88 (58.3) | Reference | Reference | ||
| GT | 15 (40.5) | 59 (39.1) | 0.94 (0.45–1.97) | 0.87 | 0.94 (0.45–1.97) | 0.86 |
| TT | 1 (2.7) | 4 (2.6) | 0.96 (0.10–8.99) | 1.00 | 1.03 (0.11–9.78) | 0.98 |
| GT + TT | 16 (43.2) | 63 (41.7) | 0.94 (0.45–1.94) | 0.88 | 0.94 (0.45–1.96) | 0.87 |
| Combined | (n = 140) | (n = 301) | ||||
| C-123A | ||||||
| CC | 105 (75.5) | 243 (81.8) | Reference | Reference | ||
| CA | 31 (22.3) | 50 (16.8) | 0.71 (0.42–1.20)c | 0.20c | 0.70 (0.41–1.18) | 0.19 |
| AA | 3 (2.2) | 4 (1.4) | 0.54 (0.11–2.72)c | 0.45c | 0.66 (0.14–3.09) | 0.60 |
| CA + AA | 34 (24.5) | 54 (18.2) | 0.69 (0.42–1.15)c | 0.16c | 0.70 (0.42–1.15) | 0.17 |
| G-88T | ||||||
| GG | 77 (55.4) | 185 (62.3) | Reference | Reference | ||
| GT | 51 (36.7) | 102 (34.3) | 0.79 (0.50–1.22)c | 0.28c | 0.83 (0.54–1.30) | 0.43 |
| TT | 11 (7.9) | 10 (3.4) | 0.42 (0.17–1.06)c | 0.07c | 0.39 (0.16–0.96) | 0.04 |
| GT + TT | 62 (44.6) | 112 (37.7) | 0.72 (0.47–1.10)c | 0.13c | 0.75 (0.49–1.15) | 0.19 |
The number of samples genotyped varies because of genotyping failure for some individuals.
OR odds ratio, CI confidence interval, NA not applicable
aORs and P values were calculated by logistic regression analysis
bORs and P values were calculated by multivariate logistic regression, adjusted for age (months) and sex
cORs and P values were calculated by Mantel–Haenszel (MH) test