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Superimposition of the INF-C virus HEF active site structure. The apo structure carbons are shown in brown and the 9-acetamido-9-deoxy-Neu5Acα2Me (6) INF-C virus HEF complex in atomic colours (αOMe not displayed). The carboxylate group (COO–) of the 9-acetamido-9-deoxy-Neu5Acβ2Me (7) is also shown (cyan). The conformational rearrangement of Ser-57 upon substrate binding is clearly observed
