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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Fertil Steril. 2020 Feb 7;113(3):569–577.e1. doi: 10.1016/j.fertnstert.2019.10.007

Table 3:

Hazard Ratios predicting mortality in women who delivered (2004-2013) while including and excluding external causes of mortality*

Maternal Characteristics All-cause mortality** Mortality (Excluding External causes)***
Unadjusted HR (95% CI) Adjusted HR (95% CI) Unadjusted HR (95% CI) Adjusted HR (95% CI)
Fertility Group
Fertile Reference Reference Reference Reference
Subfertile 0.58 (0.37–0.93) 0.89 (0.56–1.42) 0.68 (0.38–1.2) 0.75 (0.42–1.33)
ART 0.46 (0.3–0.72) 0.75 (0.48–1.18) 0.73 (0.46–1.16) 0.81 (0.50–1.30)
Mother’s Age (years) at last delivery
<25 Reference Reference Reference Reference
25–29 0.75 (0.64–0.88) 1.15 (0.98–1.35) 1.08 (0.84–1.38) 1.49 (1.16–1.91)
30–34 0.56 (0.48–0.65) 1.31 (1.11–1.55) 1.08 (0.86–1.36) 2.04 (1.59–2.61)
35–39 0.66 (0.56–0.78) 1.68 (1.4–2.01) 1.46 (1.16–1.83) 2.85 (2.21–3.67)
40+ 0.77 (0.61–0.98) 1.81 (1.41–2.32) 1.82 (1.35–2.45) 3.23 (2.35–4.44)
Race/Ethnicity
Non-Hispanic White Reference Reference Reference Reference
Hispanic 0.65 (0.55–0.78) 0.34 (0.28–0.41) 0.76 (0.6–0.95) 0.5 (0.39–0.63)
Non-Hispanic Black 1.04 (0.87–1.25) 0.54 (0.45–0.65) 1.24 (0.99–1.55) 0.71 (0.56–0.9)
Asian/Pacific Islanders 0.38 (0.28–0.51) 0.48 (0.36–0.65) 0.54 (0.39–0.76) 0.65 (0.46–0.91)
American Indians & Others 1.00 (0.69–1.44) 0.64 (0.45–0.93) 0.96 (0.58–1.58) 0.71 (0.43–1.17)
Education
<HS or HS/GED Reference Reference Reference Reference
Some college or Associate Degree 0.73 (0.62–0.86) 0.87 (0.73–1.03) 0.79 (0.63–0.98) 0.81 (0.64–1.01)
Bachelor’s degree or Post-graduate 0.31 (0.27–0.36) 0.54 (0.45–0.64) 0.48 (0.41–0.57) 0.59 (0.48–0.73)
Marital Status
Married Reference Reference Reference Reference
Not Married 3.22 (2.88–3.6) 2.38 (2.06–2.73) 1.98 (1.72–2.29) 1.84 (1.54–2.21)
Insurance at last delivery
Private Reference Reference Reference Reference
Public 2.85 (2.54–3.2) 1.84 (1.58–2.14) 1.83 (1.58–2.11) 1.49 (1.23–1.80)
History of Chronic Hypertension
No Reference Reference Reference Reference
Yes 3.47 (2.99–4.02) 2.43 (2.06–2.86) 4.77 (4–5.69) 3.22 (2.65–3.92)
Pregnancy Hypertension/Eclampsia/Preeclampsia
No Reference Reference Reference Reference
Yes 1.50 (1.21–1.86) 1.15 (0.92–1.43) 1.77 (1.35–2.3) 1.2 (0.91–1.58)
History of Chronic Diabetes
No Reference Reference Reference Reference
Yes 3.26 (2.66–4.00) 1.92 (1.54–2.38) 0.58 (0.37–0.93) 1.94 (1.49–2.54)
*

Adjusted analyses of factors associated with all-cause mortality and mortality excluding external causes are shown in Table 3. The strongest parameters predicting all-cause mortality were history of mother’s age, education, marital status, and being publically insured as well as chronic hypertension, chronic diabetes. Once adjusted, fertility group (ART, subfertility) is no longer a significant predictor of all-cause mortality. Hazard ratios in bold denote significant results at P<0.05.

**

Study sample for all-cause-mortality is based on (N=480,243). Missing covariates for education (n=1568), Race (N=527), and marital status (N=1457) were deleted for modeling purposes.

***

Study sample for mortality (excluding external causes) is based on (N= 479,693). Missing covariates for education (N=1568), Race (N=525), and marital status (N=1453) and external causes of death (N=555) were deleted for modeling purposes.

Models are simultaneously adjusted for all other maternal characteristics included in table 3.