Fig. 2.

Possible self-limitation of the autoimmune pituitary process: cytokines produced at the site of autoimmune inflammatory process stimulate CRH and AVP secretion, both stimulating cortisol secretion, through ACTH hyperproduction(CRH and AVP) or also directly(AVP), which can limit the autoimmune process if the pituitary cells are not irreversibly damaged. PV paraventricular nucleus, SO supraoptic nucleus, AVPs AVP storage in post-pituitary, IL interleukin, TNF tumor necrosis factor (from Ref. [2], with permission)