Table IV.
Contribution of Individual CDR Loop Towards Antigen Recognition
| CDR Statistics | L1 | L2 | L3 | H1 | H2 | H3 | FR |
|---|---|---|---|---|---|---|---|
| Length of CDR loop (L) | 12.0 ± 0.9 | 7.0 ± 0.0 | 9.0 ± 0.5 | 10.0 ± 0.0 | 16.9 ± 0.6 | 9.8 ± 3.0 | |
| Number of binding residues (Nb) | 2.6 ± 1.2 | 2.0 ± 2.1 | 4.0 ± 1.4 | 3.1 ± 1.8 | 5.7 ± 2.3 | 4.7 ± 1.8 | 0.8 ± 1.4 |
| Ratio 1 (%, Nb / L) | 21.7 | 28.6 | 44.4 | 31.0 | 33.7 | 48.0 | |
| Percentage of buried surface area of Fab (SA buried) | 12.3 ± 8.4 | 7.4 ± 7.5 | 17.3 ± 8.6 | 12.1 ± 8.3 | 23.5 ± 10.9 | 25.0 ± 13.8 | 2.3 ± 5.1 |
| Ratio 2 (SA buried / Nb) | 4.7 | 3.7 | 4.3 | 3.9 | 4.1 | 5.3 | |
| Number of hydrogen bonds and ion pairs | 1.6 ± 1.6 | 0.7 ± 1.0 | 2.1 ± 1.7 | 1.8 ± 1.7 | 3.5 ± 2.6 | 3.1 ± 2.0 |