Table 1.
Virus reduction factors (LRVs) achieved by filtration with Planova filters in the manufacturing process of different blood products (confidence intervals not shown)
| Product | Filtera | Virusb | References | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| B19 V | CPV | PPV | HAV | EMCV | WNV | BVDV | HIV-1 | PRV | |||
| Coagulation factor VIII (cross eight M®) | 35N (DE) | <1.0 | – | – | – | 1.5 | – | >5.3 | – | >4.9 | Furuya et al. (2006) |
| 20N (DE) | 4.9 | – | >5.1 | >3.4 | >5.8 | – | >4.6 | – | >4.0 | ||
| Coagulation factor VIII (Beriate®) | 20N | – | 3.4 | – | ≥5.5 | – | – | ≥5.8 | ≥6.0 | ≥7.2 | Gröner (2014) |
| Coagulation factor VIII (Factane®) | 35N + 15N (DE) | – | – | ≥6.1 | ≥3.6 | – | – | ≥4.1 | ≥3.8 | ≥4.9 | Chtourou et al. (2007) |
| Coagulation factor IX (Replenine®-VF) | 15N (DE) | – | – | – | >6.0 | 5.7 | – | – | >6.6 | – | Roberts et al. (2010) |
| Human normal immunoglobulin (Nanogam®) | 15N (T)c | >6.1 | >3.4 | – | – | >5.8 | – | >6.3 | >5.4 | >6.1 | Terpstra et al. (2006) |
| 15N + 15N (T)d | >6.1 | >3.9; ≤4.1 | – | – | >5.8 | – | >6.3 | >5.4 | >6.1 | Koenderman et al. (2012) | |
| 20N + 20N (DE)d | >4.3; ≤5.1 | >5.8 | >7.2 | >6. | >6.4 | ||||||
| Human intravenous IgG (IVIG) | 35N (DE) | – | – | <1.0 | – | – | – | >4.9 | >5.2 | >4.6 | Dichtelmüller et al. (2012) |
| C1 esterase inhibitor (C1-INH) (Cetor®) | 15N (DE) | – | >4.5 | – | >4.9 | – | – | >5.5 | >5.6 | >6.4 | Terpstra et al. (2007) |
| C1-INH | 20N + 15N (DE) | – | ≥7.2 | ≥5.3 | – | – | ≥8.0 | ≥5.3 | ≥5.1 | ≥7.1 | Gröner et al. (2012) |
| Holotransferrin | 15N + 15N (DE) | – | >6.9 | – | >5.6 | – | – | >7.5 | >6.3 | >6.8 | Koenderman et al. (2012) |
| Plasma-derived proteinse | 15/20N | – | – | 4.9 | – | 5.3 | ≥5.5 | 4.7 | ≥5.5 | ≥5.3 | Caballero et al. (2014) |
a DE dead-end (normal) mode, T tangential mode. Filters were associated in series in DE and in parallel in T
bSee Table 2
cFiltration step combined with pepsin treatment at pH 4·4
dExperiments were performed in duplicate; the lowest LRV is given. The filtration step was combined with low pH (4.4) inactivation for enveloped viruses (BVDV, HIV, PRV)
eSeven plasma proteins (and 2 types of Planova filters) were involved (mean LRV values are given)