Table 2.

Signalment with principal pathological findings and syndromes in cattle infected with H. somni

Farms	Animals	Gross alterations	Histopathology	Pathological syndrome
A	1: 1-day-old Nelore calf	Bloody fluid within the intestine	Hemorrhagic ruminitis	Systemic histophilosis
		Cerebrum; shallow sulci with distended gyri	Cerebellum; meningoencephalitis with vasculitis, thrombosis and infarctions
		Congestion of cerebral cortex	Lymphadenitis with vasculitis, congestion, and edema
		Corneal opacity	Necrohemorrhagic enteritis
		Hemorrhage of meningeal vessels	Pulmonary edema and hemorrhage
		Hemorrhagic rhinotracheitis	Renal hemorrhages
		Lymphadenopathy	Vasculitis (myocardial, renal, and pulmonary)
		Pulmonary hemorrhage
		Ruminal and abomasal hemorrhages
	2: 7-day-old Nelore calf	Abomasal ulcerations	Abomasal ulcerations	Systemic histophilosis
		Arthritis	Cerebrum and cerebellum; vasculitis
		Blood-filled intestine	Centrilobular hepatocellular necrosis
		Cardiac valvular thrombosis	Hemorrhagic enteritis
		Foamy secretion within trachea	Hepatitis with thrombosis and vasculitis
		Lymphadenopathy	Lymphadenitis with vasculitis, congestion, and edema
		Pale areas at the myocardium	Necrotizing myocarditis with vasculitis and dystrophic mineralization
		Wet and heavy lungs	Pulmonary edema
B	3: 20-day-old Nelore calf	Cerebrum; shallow sulci with distended gyri	Hepatic abscesses and thrombosis	Systemic histophilosis
		Congestion of meningeal vessels	Kidney, vasculitis and thrombosis
		Pale hepatic foci (0.2–0.5 cm diameter)	Meningoencephalitis with vasculitis, thrombosis and infarctions
		Pulmonary hemorrhage	Myocarditis with vasculitis
		Congestion of meningeal vessels	Pleuropneumonia
C	4: 8-month-old Girolando fetus	Abomasal hemorrhages	Pulmonary hemorrhage with vasculitis and thrombosis	Abortion
		Brain; shallow sulci with distended gyri	Meningoencephalitis with vasculitis and thrombosis
D	5: 60-day-old Shorthorn calf	Congestion of cerebral cortex	Vasculitis (myocardial and renal)	Systemic histophilosis
		Hemorrhage of meningeal vessels	Bronchopneumonia
		Cranioventral consolidation of lung	Hemorrhagic enteritis
		Pale areas at the wall of the left myocardial ventricle	Hepatitis with vasculitis and thrombosis and sinusoidal congestion
		Epicardial and endocardial petechiae	Lymphadenitis with vasculitis, congestion, and edema
		Fetid diarrhea with	Meningoencephalitis with vasculitis and thrombosis
		Lymphadenopathy	Multifocal coagulative cortical renal necrosis and vasculitis
		Several wedge-shaped pale areas at the cortex of the kidney (Renal infarctions)	Necrotizing myocarditis with vasculitis
		Thymus hemorrhages