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Potential mechanisms involved in the antifibrotic actions of RLX and CGP, with inhibitory mechanisms depicted by red line blocks. RXFP1 and AT2R stimulation reduced inflammatory and pro-fibrotic factors thereby inhibiting myofibroblast differentiation and ECM production while enabling ECM degradation by inhibiting TIMP-1. In contrast, CAND inhibited fewer mechanisms in this pathway. Line blocks represent inhibition; dotted line block represents inhibitory trend.
