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CDC25i, high concentrations of CDK1/2i, and CDC7i prevent loading of CDC45 on chromatin. MDA-MB-231 cells were incubated with SN38 for 24 h and then with CHK1i for an additional 2 h. CDC25i, CDK1/2i, or CDC7i were administered concurrently with CHK1i as indicated. Soluble and chromatin-bound proteins were separated and probed for the indicated proteins by Western blotting.
