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. 2018 Oct 12;1(2):84–95. doi: 10.1021/acsptsci.8b00007

Figure 5.

Figure 5

Aglycone polyether J1-001-1 inhibits paclitaxel-resistant MCF-7 tumor growth in vivo. BALB/c mice were injected with paclitaxel-resistant MCF-7 breast cancer cells prior to exposure to the compounds. Each group was given by corresponding sterile drugs through intraperitoneal injection by every 3 days of a 20 day cycle. (A) Effect of J1-001-1 on tumor burden. J1-001-1-L (0.25 mg/kg), J1-001-1-M (0.5 mg/kg), J1-001-1-H (1 mg/kg), paclitaxel (10 mg/kg), or vehicle control was injected intraperitoneally. Tumor volumes were measured at the indicated times. (B) The inhibitory effect on tumor weight of paclitaxel, J1-001-1-L, J1-001-1-M, and J1-001-1-H. ***, P < 0.01; ****, P < 0.001. (C) The inhibitory effect of nanchangmycin (J1-001-1) on paclitaxel-resistant MCF-7 tumor growth compared with the control.