Figure 2.

Overview of BMPs actions in organ development, tissue homeostasis, and disease pathology. BMPs play a role in several cellular processes important in organ development, with BMP deletion leading to severe organ abnormalities. Beyond development, the TGFβ/BMP signaling is finely balanced, maintaining tissue homeostasis. When this balance is lost, aberrant signaling drives tissue remodelling in several organs, including organs commonly affected by diabetes. Figure created using artwork provided by Servier Medical Art by Servier, licensed under a Creative Commons License (CC BY 3.0).