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. 2020 Jan 23;3(1):148–160. doi: 10.1021/acsptsci.9b00085

Table 1. Median Survival of Nude Mice Harboring MYCN-Amplified BE(2)-C or Non-amplified SK-N-AS Xenograft Tumors.

  treatment (mice per cohort) median survival (days) log-rank test (vs vehicle) log-rank test (vs perifosine) log-rank test (vs vincristine)
xenograft model of BE(2)-C vehicle (n = 8) 18 N/A 0.132 0.541
perifosine (n = 8) 20 mg/kg per os, 5 days per week 20 0.132 N/A 0.529
vincristine (n = 8) 0.2 mg/kg i.v., 5 days 20 0.541 0.529 N/A
vincristine + perisofine (n = 7) 31 0.016 0.039 0.026
xenograft model of SK-N-AS vehicle (n = 8) 21 N/A 0.33 0.369
perifosine (n = 8) 15 mg/kg per os, 5 days per week 19 0.33 N/A 0.455
vincristine (n = 8) 0.2 mg/kg i.v., 5 days 26 0.369 0.455 N/A
vincristine + perisofine (n = 8) 28 0.008 0.003 0.063