Table 1. Median Survival of Nude Mice Harboring MYCN-Amplified BE(2)-C or Non-amplified SK-N-AS Xenograft Tumors.
treatment (mice per cohort) | median survival (days) | log-rank test (vs vehicle) | log-rank test (vs perifosine) | log-rank test (vs vincristine) | |
---|---|---|---|---|---|
xenograft model of BE(2)-C | vehicle (n = 8) | 18 | N/A | 0.132 | 0.541 |
perifosine (n = 8) 20 mg/kg per os, 5 days per week | 20 | 0.132 | N/A | 0.529 | |
vincristine (n = 8) 0.2 mg/kg i.v., 5 days | 20 | 0.541 | 0.529 | N/A | |
vincristine + perisofine (n = 7) | 31 | 0.016 | 0.039 | 0.026 | |
xenograft model of SK-N-AS | vehicle (n = 8) | 21 | N/A | 0.33 | 0.369 |
perifosine (n = 8) 15 mg/kg per os, 5 days per week | 19 | 0.33 | N/A | 0.455 | |
vincristine (n = 8) 0.2 mg/kg i.v., 5 days | 26 | 0.369 | 0.455 | N/A | |
vincristine + perisofine (n = 8) | 28 | 0.008 | 0.003 | 0.063 |