Figure 3.

Molecular signatures of fusion: Identification and characterization of gene fusion subgroups. (a) Scree plot showing the eigenvalues and cumulative variance explained by successive PCs. (b) Loadings for the first 6 PCs. (c) Clusters of gene fusion events emerging from hierarchical clustering on the first 10 PCs. (d) Fusion proteins plotted by PC1 and PC2 values, colored by cluster. (e) Composition trends of fusion events by cluster. For each of the three fusion event clusters, the proportions of fusions arising from different combinations of proteins from the previously identified parent protein clusters (see Figure 2) are shown. (f) Distributions of key features of fusion events colored by cluster. (g) Paragon gene fusion events by cluster. (h) Prevalence of the three gene fusion clusters among a range of cancer types.