Skip to main content
. 2018 Oct 16;1(2):119–133. doi: 10.1021/acsptsci.8b00019

Figure 7.

Figure 7

PAR2 ligands SLIGKV, 2f-LIGRLO, GB110, and GB88 display similar pharmacophoric groups with a polar or heterocyclic motif in the first position (orange) and a hydrophobic residue in the second (blue) and third (green) positions. The models of SLIGKV and GB88 suggested that the first position was overlapping with the imidazole moiety of the small molecule antagonist AZ8838 and that none of the agonists exploited the pocket occupied by the 4-fluoro-2-propylphenyl moiety. New compounds that probed a lipophilic extension of the agonist SLIGKV were designed (yellow).