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Predicted binding mode of peptide agonists in PAR2. Peptide residues are depicted as orange spheres and numbered according to their position. Hydrophobic (side chains shown as green ellipses) and charge-charge (red spheres) interactions were mapped through mutagenesis and modeling. Interactions of the residue at position 6 were not probed by mutagenesis and the region occupied by the side chain is expected to be dynamic.
