. 2018 Oct 16;1(2):119–133. doi: 10.1021/acsptsci.8b00019

Table 3. Potency Data Probing Hydrophobic Interactions of Mutant Peptide Agonists and WT PAR2 Receptor^a.

peptide	pEC₅₀ ± s.e.m.	peptide	pEC₅₀ ± s.e.m.
SLIGKV	6.06 ± 0.03	SLAGKV	4.83 ± 0.03
SAIGKV	<3.5	SL[Chg]GKV	6.58 ± 0.04
S[Cha]IGKV	6.41 ± 0.05	SLMGKV	5.94 ± 0.05
S[Hph]IGKV	4.61 ± 0.06	SLWGKV	4.43 ± 0.07
S[Igl]IGKV	4.81 ± 0.06	SL[Thr(tBu)]GKV	<3.5
SLAAAA	4.27 ± 0.05	SL[2Nal]GKV	<3.5

pEC₅₀ values, measured by calcium mobilization assays, are presented as mean ± s.e.m. (n = 3 independent experiments).

Table 3. Potency Data Probing Hydrophobic Interactions of Mutant Peptide Agonists and WT PAR2 Receptora.