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. 2018 Oct 16;1(2):119–133. doi: 10.1021/acsptsci.8b00019

Table 5. Potency Data Probing C-Terminal Interactions of Peptide Agonists at Mutant PAR2 Receptorsa.

  SLIGKV SLIGEV SLIGAV
WT 6.06 ± 0.03 4.69 ± 0.06 5.16 ± 0.04
E232AECL2 5.18 ± 0.04 4.64 ± 0.06 4.70 ± 0.08
E232QECL2 5.18 ± 0.07 4.44 ± 0.07 4.64 ± 0.09
E232RECL2/N222QECL2 4.85 ± 0.03 5.02 ± 0.05 4.60 ± 0.05
a

pEC50 values, measured by calcium mobilization assays, are presented as mean ± s.e.m. (n = 3 independent experiments).