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. 2019 Mar 18;2(3):183–197. doi: 10.1021/acsptsci.9b00010

Figure 4.

Figure 4

Alanine mutation of ECL2 and ECL3 of AMY3R has limited effect on pERK functional affinity (log KA). Functional affinities derived from operational fitting of concentration–response curves in ERK phosphorylation for alanine mutation of ECL2 (A–E) and ECL3 (F–J) are displayed as log KA. No significant changes in log KA from WT were seen for receptor mutants following one-way ANOVA and Dunnett’s post-test with P < 0.05 accepted as significant. Where data were insufficiently robust to derive a reliable value for log KA no symbol is shown (ND). Quantitative data are reported in Table 3.