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. 2019 Aug 2;2(6):387–401. doi: 10.1021/acsptsci.9b00041

Figure 5.

Figure 5

Priming of αVβ3. HEK-αVβ3 cells were either untreated (control) or incubated with 1 μM cilengitide, 100 μM RGDS, or 10 μM TDI-4161 or TDI-3761 for 20 min at room temperature, fixed with paraformaldehyde, washed, and incubated with fluorescent fibrinogen. After washing, cell-bound fluorescence was determined by flow cytometry. Compared to the control, both RGDS and cilengitide increased the amount of bound fibrinogen, whereas TDI-4161 and TDI-3761 did not. N = 7 for all values except TDI-3761, where n = 3.