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. 2019 Dec 30;3(1):107–118. doi: 10.1021/acsptsci.9b00087

Figure 4.

Figure 4

SHEATH system based on the noncovalent nanoconjugate between a recombinant TCS protein and the endogenous albumin. After injection, such a multifunctional fusion protein would bind with the endogenous serum albumin in the bloodstream and hitchhike to the tumor site for enhanced accumulation, where the protease-substrate peptide would be cleaved and the rTCS fragment unhitched from the carrier for taking pharmacological action. Reprinted with permission from ref (82). Copyright 2019 Royal Society of Chemistry.