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Peptide SAA-1525 identification. (A) SAA-1525 LC-MS signal normalized to spiked-in ACTH fragment (Mean ± SE; **, p < 0.01 by two-way ANOVA). (B) ROC analysis for SAA-1525 differentiation of Ctox and nCtox patients. (C) SAA-1525 peptide peak LC-MS/MS sequence. (D) CTSB cleavage sites in SAA1. Blue arrows indicate CTSB cleavage sites. * indicates a cleavage site not assigned to CTSB activity.
