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SAA-1525 production is CSTB-dependent. ACTH-normalized LC-MS signal for cleavage of recombinant SAA1 to (A) SAA-1525 and (B) SAA-2126 and (C) cleavage of synthetic SAA-2126 peptide to SAA-1525 in human plasma with high and low CTSB levels. Mean ± SE; ****, p < 0.0001 by Student’s t test. (D) Cleavage of SAA1 to SAA-1525 in human plasma treated with or without the CTSB-specific inhibitors E64 and ALLM.
