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. 2020 Jan 21;63(3):457–460. doi: 10.1007/s11427-020-1637-5

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

Xintian Xu 1,#, Ping Chen 2,5,#, Jingfang Wang 3,#, Jiannan Feng 4, Hui Zhou 2, Xuan Li 2,, Wu Zhong 4,, Pei Hao 1,5,6,
PMCID: PMC7089049  PMID: 32009228

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Electronic supplementary material

Supporting Information (229.7KB, pdf)
Supporting Information (325.7KB, pdf)

Acknowledgements

This work was supported in part by grants from the National Science and Technology Major Projects for “Major New Drugs Innovation and Development” (directed by Dr. Song Li) (2018ZX09711003) of China, the National Key R&D Program (2018YFC0310600) of China, the National Natural Science Foundation of China (31771412), and Special Fund for strategic bio-resources from Chinese Academy of Sciences (ZSYS-014). We also acknowledge the National Institute for Viral Disease Control and Prevention, China CDC; Wuhan Institute of Virology, Chinese Academy of Sciences; Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College; and Wuhan Jinyintan Hospital for their efforts in research and collecting the data and genome sequencing sharing. In addition, we acknowledge GISAID (https://www.gisaid.org/) for facilitating open data sharing.

Compliance and ethics The author(s) declare that they have no conflict of interest.

Footnotes

Contributed equally to this work

Contributor Information

Xuan Li, Email: lixuan@sippe.ac.cn.

Wu Zhong, Email: zhongwu@bmi.ac.cn.

Pei Hao, Email: phao@ips.ac.cn.

References

  1. CDC . 2019 Novel Coronavirus (2019-nCoV), Wuhan, China. 2020. [Google Scholar]
  2. Cotten M, Watson SJ, Kellam P, Al-Rabeeah AA, Makhdoom HQ, Assiri A, Al-Tawfiq JA, Alhakeem RF, Madani H, AlRabiah F A, et al. Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study. Lancet. 2013;382:1993–2002. doi: 10.1016/S0140-6736(13)61887-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hu B, Zeng LP, Yang XL, Ge XY, Zhang W, Li B, Xie JZ, Shen XR, Zhang YZ, Wang N, et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog. 2017;13:e1006698. doi: 10.1371/journal.ppat.1006698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Li F. Evidence for a common evolutionary origin of coronavirus spike protein receptor-binding subunits. J Virol. 2012;86:2856–2858. doi: 10.1128/JVI.06882-11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Li F, Li W, Farzan M, Harrison SC. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005;309:1864–1868. doi: 10.1126/science.1116480. [DOI] [PubMed] [Google Scholar]
  6. Maier JA, Martinez C, Kasavajhala K, Wickstrom L, Hauser KE, Simmerling C. ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB. J Chem Theor Comput. 2015;11:3696–3713. doi: 10.1021/acs.jctc.5b00255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Normile D. Mystery virus found in Wuhan resembles bat viruses but not SARS, Chinese scientist says. 2020. [Google Scholar]
  8. Raj VS, Mou H, Smits SL, Dekkers DHW, Müller MA, Dijkman R, Muth D, Demmers JAA, Zaki A, Fouchier RAM, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature. 2013;495:251–254. doi: 10.1038/nature12005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Schwede T, Kopp J, Guex N, Peitsch MC. SWISSMODEL: an automated protein homology-modeling server. Nucleic Acids Res. 2003;31:3381–3385. doi: 10.1093/nar/gkg520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Shu Y, McCauley J. EuroSurveillance. 2017. GISAID: Global initiative on sharing all influenza data—from vision to reality. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. WHO . Pneumonia of unknown cause in China. 2020. [Google Scholar]
  12. Zhang YZ. Initial genome release of novel coronavirus. 2020. [Google Scholar]

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Supplementary Materials

Supporting Information (229.7KB, pdf)
Supporting Information (325.7KB, pdf)

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