Table 2.
Characterization of hPIV common structural proteins
| Localisation | Protein | Function |
|---|---|---|
| Associated with vRNA (nucleocapsid formation) | L | RNA-dependent RNA polymerase |
| P | Phosphoprotein subunit of the RNA-dependent RNA polymerase | |
| N | Nucleocapsid protein | |
| Surface glycoproteins | HN | Haemagglutinin-neuraminidase, found on the lipid envelope of hPIV and infected cells, functions in virus-host cell attachment via sialic acid receptors |
| F | Fusion protein that allows the viral nucleocapsid to enter and infect a host cell; required for membrane fusion between host cells (syncytial formation) | |
| M | Matrix protein with a role in attaching nucleocapsids to areas of the infected cell membrane, generating the viral envelope; may be involved in viral budding |