Table 2.
Characterization of hPIV common structural proteins
Localisation | Protein | Function |
---|---|---|
Associated with vRNA (nucleocapsid formation) | L | RNA-dependent RNA polymerase |
P | Phosphoprotein subunit of the RNA-dependent RNA polymerase | |
N | Nucleocapsid protein | |
Surface glycoproteins | HN | Haemagglutinin-neuraminidase, found on the lipid envelope of hPIV and infected cells, functions in virus-host cell attachment via sialic acid receptors |
F | Fusion protein that allows the viral nucleocapsid to enter and infect a host cell; required for membrane fusion between host cells (syncytial formation) | |
M | Matrix protein with a role in attaching nucleocapsids to areas of the infected cell membrane, generating the viral envelope; may be involved in viral budding |