Fig. 2.

Proteasome inhibitors inhibit IBDV-induced CPE. (A) DF-1 cells were infected with IBDV (MOI = 50) and then treated with various concentrations of MG132 as described in Materials and methods. Cell viability was assessed by the MTS assay at 21 h p.i. The values of MTS in mock-infected cells in the absence of MG132 were defined as 100% survival. Values are means ± SE of three independent experiments. (B) Representative morphological changes of DF-1 cells treated with MG132 or DMSO at 21 h p.i. by phase-contrast microscopy. Bars, 10 μm