Table 2.
The role of ROS in various diseases
| Positive | Negative | |
|---|---|---|
| Cancer |
Impair tumourigenesis Apoptosis |
High metastasis Canceration Radioresistance Carcinogenesis |
| Inflammatory diseases |
Prevent experimental autoimmune encephalomyelitis Supports immune system Macrophage killing |
Inflammatory bowel diseases Parasite caused organic damage Periodontitis Tendinopathy Bronchitis Emphysema Rheumatoid arthritis |
| Neurologic diseases |
Synaptic plasticity Neuronal development |
Movement disorder Neuron apoptosis Neurotoxicity Retardation |
| Vascular diseases |
Relaxation of cerebral arteries Blood flow homeostasis |
Hypertension Vascular injury |
| Wound repair |
Ischaemia–reperfusion damage Retinal dysfunction Pneumoconiosis Atherosclerosis Acute respiratory distress syndrome |
|
| Organ failure |
Respiratory plasticity Sensory plasticity |
Liver failure Renal failure Heart failure |
| Diabetes | Insulin resistance | |
| Ageing |
Muscle cell development Muscle remodelling |
Sarcopenia Muscular dystrophy DNA damage |
| Infertility |
Damage spermatogenesis Ovarian toxicity |