TABLE 2.
Spearman Correlations (rs) of Change in HRQL With Critical Illness Variables
| Severity of Illness Measures | # PedsQL™ | # FSII-R | Δ PedsQL™ Month 3 rs (95% CI) | Δ FSII-R Month 3 rs (95% CI) |
|---|---|---|---|---|
| PRISM-IV | 122 | 81 | −0.11 (−0.282, 0.069) | −0.013 (−0.231, 0.205) |
| PELOD, Day 0 | 122 | 81 | −0.176 (−0.343, 0.002) | 0.012 (−0.207, 0.23) |
| PELOD, First Day | 122 | 81 | −0.142 (−0.312, 0.037) | 0.009 (−0.21, 0.227) |
| Sum of PELOD-2 in PICU | 122 | 81 | −0.276 (−0.433, −0.104) | −0.236 (−0.432, −0.019) |
| PRBC first transfusion (relative to Day 0) | 63 | 32 | 0.071 (−0.18, 0.313) | −0.43 (−0.677, −0.096) |
| Highest VIS in PICU | 122 | 81 | −0.14 (−0.31, 0.038) | 0.013 (−0.206, 0.231) |
| Sum of VIS in PICU | 122 | 81 | −0.187 (−0.353, −0.009) | −0.142 (−0.35, 0.079) |
| Mechanical ventilator days | 122 | 81 | −0.194 [−0.359, −0.016] | −0.207 [−0.407, 0.012] |
| PICU length of stay (days) | 122 | 81 | −0.235 (−0.396, −0.06) | −0.26 (−0.452, −0.044) |
| Hospital length of stay (days) | 122 | 81 | −0.254 (−0.413, −0.08) | −0.227 (−0.424, −0.009) |
| PCPC CFB at Day 28 (>0 is worsening) | 122 | 81 | −0.165 (−0.333, 0.014) | 0.01 (−0.209, 0.228) |
| PCPC CFB at Day 7 (>0 is worsening) | 122 | 81 | −0.188 (−0.354, −0.01) | −0.038 (−0.254, 0.182) |
| POPC CFB at Day 28 (>0 is worsening) | 122 | 81 | −0.284 (−0.44, −0.112) | −0.165 (−0.37, 0.055) |
| POPC CFB at Day 7 (>0 is worsening) | 122 | 81 | −0.251 (−0.41, −0.076) | −0.172 (−0.376, 0.048) |
| FSS CFB at Day 28 (>0 is worsening) | 122 | 81 | −0.368 (−0.513, −0.204) | −0.301 (−0.488, −0.089) |
| FSS CFB at Day 7 (>0 is worsening) | 121 | 80 | −0.259 (−0.418, −0.085) | −0.272 (−0.464, −0.055) |
| PedsQL™ Baseline | 122 | . | −0.531 (−0.647, −0.39) | |
| PedsQL™ CFB at Day 7 | 112 | . | 0.393 (0.223, 0.539) | |
| PedsQL™ CFB at Day 28 | 106 | . | 0.692 (0.577, 0.78) | |
| FSII-R Baseline | . | 81 | −0.532 (−0.672, −0.355) | |
| FSII-R CFB at Day 7 | . | 69 | 0.365 (0.14, 0.554) | |
| FSII-R CFB at Day 28 | . | 65 | 0.563 (0.37, 0.709) |
Abbreviations: rs, Spearman correlation; HRQL, health-related quality of life; PedsQL™, Pediatric Quality of Life Inventory; FSII-R, Stein-Jessop Functional Status Scale; PRISM-IV, Pediatric Risk of Mortality score, version IV; PELOD-2, Pediatric Logistic Organ Dysfunction score, version 2; PICU, pediatric intensive care unit; PRBC, packed red blood cells; VIS, Vasoactive-Inotropic Score; PCPC, Pediatric Cerebral Performance Category; CFB, change from baseline; POPC, Pediatric Overall Performance Category; FSS, Functional Status Scale;