TABLE 3.

Selected Multivariable Models for Mortality, PSD-HRQL, and Mortality or PSD-HRQL at Month 3

	Mortality Odds Ratio (95% CI) [P-Value]	PSD-HRQL Odds Ratio (95% CI) [P-Value]	Mortality or PSD-HRQL Odds Ratio (95% CI) [P-Value]
	Δ BIC = 0.6	Δ BIC = 0.0	Δ BIC = 0.0
Variable	Modeling Based on 341 Complete Records	Modeling Based on 201 Complete Records	Modeling Based on 229 Complete Records
∑ Daily PICU PELOD Scores	--------	1.01 (1.01, 1.02) [<0.001]	1.01 (1.01, 1.02) [<0.001]
Highest VIS in PICU	--------	--------	1.02 (1.00, 1.04) [0.003]
Pathologic Neurologic Signs/Events
No	--------	--------	Reference
Yes	--------	--------	5.04 (2.15,12.01) [<0.001]
Age (years)	--------	1.13 (1.04, 1.23) [0.003]	--------
Sum of VIS in PICU	1.01 (1.00, 1.01) [<0.001]	--------	--------
Anisocoria or absence of pupillary response
No	Reference	--------	--------
Yes	5.26 (2.06, 13.20) [<0.001]	--------	--------

Abbreviations: PSD-HRQL, persistent, severe health-related quality of life deterioration, defined as > 25% below baseline health-related quality of life, as assessed at Month 3; BIC, Bayesian information criterion; PICU, pediatric intensive care unit; PELOD, Pediatric Logistic Organ Dysfunction, version 2; VIS, Vasoactive-Inotropic Score; PICU, pediatric intensive care unit