. 2018 Dec 28;36(2):30. doi: 10.1007/s11095-018-2551-x

Table IV.

Ontogeny and Impact of Pregnancy on AAG Protein Levels in Plasma or Serum

Species/Strain	AAG mean or range (mg/ml) ± Standard deviation / Age or pregnancy status			Reference
Species/Strain	Fetus/Age	Newborn/Age	Adult/Age or pregnancy status	Reference
Minipig/Gottingen		0.34 (0.25–0.53)/6 weeks	0.29 (0.23–0.41)/40–48 weeks	(19)
		0.41 (0.34–0.47)/16 weeks
		0.33 (0.26–0.38)/24 weeks
Minipig/Gottingen			0.3/14–16 months	(14)
Minipig/Ossabaw			0.5/41–47 months	(14)
Pig/Conventional crossbred (Landrace Yorkshire)			0.6/8–9 months	(14)
Pig/Conventional crossbred (Duroc Yorkshire Landrace)		6.6/2–5 days	1.1/26–31 days	(14)
Pig/Conventional crossbred (Landrace White)		14.3 ± 2.4/1 days	0.34 ± 0.08/5–10 months	(15)
		6.1 ± 1.6/4 days
		1.3 ± 0.5/2 weeks
	12.7		0.24	(16)
Dog/Beagle	<0.04/cord		0.32 (0.04–0.96)/male	(25)
			0.32(0.05–0.83)/female
			0.63 (0.25–1.0)/pregnant female
Monkey/Rhesus			0.43–0.52/pregnancy 13–18 weeks	(59)
			0.70/pregnancy 19 weeks
			0.90/pregnancy 21 weeks
			1.35/pregnancy 22 weeks
			1.90/pregnancy 24 weeks
			1.55–1.70/postpartem 1–3 days
Human		0.14 ± 0.20/cord neonate	0.65 ± 0.13/pregnancy trimester 1	(53)
			0.51 ± 0.24/pregnancy trimester 2
			0.44 ± 0.12/pregnancy trimester 3
			0.89 ± 0.20/postpartum mother
			0.64 ± 0.10/non-pregnant female
	BLQ–0.15/12–23 weeks		0.50–1.05/pregnant female 12–23 weeks	(56)
	0.06–0.33/27–34 weeks		0.50–1.05/pregnant female 12–23 weeks
	0.08–0.41/35–41 weeks		0.38–0.99/pregnant female 27–34 weeks
	0.08–0.41/35–41 weeks		0.29–0.88/pregnant female 35–41 weeks
	0.05 (0.02–0.2)/19–34 weeks		0.7 (0.45–0.9)/non-pregnant female	(57)
			0.55 (0.35–0.8)/pregnant female
			0.08 (0.01–0.1)/amniotic fluid
		0.24/cord neonate	0.60	(47)
		0.1–0.3/neonate	0.7–2.5/postpartum mother	(54)
		0.34 ± 0.15/30–36 weeks		(58)
		0.46 ± 0.19/1–12 months
		0.66 ± 0.28/1–5 years
		0.63 ± 0.16/12–18 years
		0.13–0.20/birth	0.94 ± 0.22/2 years	(34)
		0.52 ± 0.24/1–2 months	0.84 ± 0.18/3–4 years
		0.58 ± 0.25/2–3 months	0.88 ± 0.21/5–9 years
		0.82 ± 0.20/10 months
		0.42 ± 0.17/7 weeks male		(50)
		0.33 ± 0.14/10 weeks female		(50)
		0.25	0.7	(33)
	0.15 ± 0.05/cord		0.50 ± 0.07/pregnant female	(51)
			0.50 ± 0.07/non-pregnant female
			0.39 ± 0.08/male
		0.28^a (0.13–0.56)^b/birth	0.83^a (0.52–1.26)^b	(55)
		0.48^a (0.31–0.93)^b/1 month
		0.67^a (0.41–0.97)^b/3 months
		0.70^a (0.43–1.49)^b/6 months

BQL, below limit of quantitation

^a50^th percentile values

^b5^th, 95th percentile values