. 2018 Dec 28;36(2):30. doi: 10.1007/s11095-018-2551-x

Table V.

Genetic Variants of Human AAG

Gene^a	Protein^a	Collective variant	Individual variant	Binding pocket lobes	Drug binding selectivity	Variant molar ratio (F1*S/A)
Gene^a	Protein^a	Collective variant	Individual variant	Binding pocket lobes	Drug binding selectivity	Healthy	Disease
ORM1	AAG-A	F1*S	F1	I, II, III	lower	2–3	up to 8
			F2
			S
ORM2	AAG-B	A	A	I, II	higher	1	1
ORM2	AAG-B′	A	A	I, II	higher	1	1

References (65,66)

^aGene and protein nomenclature used interchangeably in literature