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. 2020 Mar 23;15(3):e0230586. doi: 10.1371/journal.pone.0230586

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© 2020 Derish et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) E17.5 Vangl2^Fl/Fl (upper image) and null Vangl2^Δ/Δ (lower image) embryos. (B) Immunofluorescence staining of E17.5 Vangl2^Fl/Fl and Vangl2^Δ/Δ kidney sections with LTA (green), E-cadherin (marker for lateral cell connections, red) and DAPI (blue); cystic and dilated proximal tubules are indicated by arrows. Scale bars, 100 μm. (C) Immunofluorescence staining of E17.5 Vangl2^Fl/Fl and Vangl2^Δ/Δ kidney sections with DBA (green), E-cadherin (red) and DAPI (blue); cystic and dilated collecting ducts indicated by arrows. Scale bars, 100 μm. (D) Measurements of proximal tubule (PT) area ratio and cell count: Vangl2^Fl/Fl (n = 80), Vangl2^Δ/Δ (n = 77). (D) Measurements of collecting duct (CD) area ratio and cell count: Vangl2^Fl/Fl (n = 88), Vangl2^Δ/Δ (n = 86). (E) Percentage of events within a given range of tubular cross-sectional area of proximal tubules. (F). Percentage of events within a given range of tubular cross-sectional area of collecting duct tubules. Mean ± standard error of mean is shown in all graphs. p<0.05 (*), p<0.001 (**), p <0.0001 (***).