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. 2020 Feb 24;143(3):976–992. doi: 10.1093/brain/awaa011

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Correlation between eigenvector centrality during hippocampal downregulation and CSF p-tau levels. The effects of age, sex, number of APOE ε4 alleles, hippocampal volume, cognitive reserve and neurofeedback performance were modelled and controlled (z > 2.326, P < 0.05 whole-brain corrected, 95% confidence interval). Note that CSF p-tau levels are proportional to the presence of neurofibrillary tangles in the brain. These results suggest that Alzheimer’s disease-characteristic EC differences in the ACC may occur earlier than previously believed.