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Correlation between eigenvector centrality during hippocampal downregulation and age. The effects of sex, number of APOE ε4 alleles, hippocampal volume, cognitive reserve, neurofeedback performance, CSF amyloid-β42 and p-tau levels were modelled and controlled (z > 2.326, P < 0.05 whole-brain corrected, 95% confidence interval). In relation to Fig. 3, these results show that EC in the cingulate and BA2 present the opposite patterns in healthy ageing.
