Table 3.

Results of ECM in relation to CSF biomarkers and age, corrected for whole-brain multiple comparisons (P < 0.05)

Brain regions	MNI coordinates, x y z	Cluster size, mm³	z-value, max (mean)
Amyloid-β correlation with EC during CA1 downregulation
ACC, BA24, BA32	3 24 28	405	−3.34 (−2.65)
L BA4	−21 −27 70	405	−2.73 (−2.49)
R BA4	18 −33 61	594	−2.91 (−2.56)
P-tau correlation with EC during CA1 downregulation
ACC, BA32 (BA10)	12 42 13	513	3.31 ( 2.66)
R Caudate, NAc, Putamen	15 21 −2	513	3.53 ( 2.86)
L Caudate, NAc, Putamen	−12 18 −5	756	3.84 ( 2.87)
L BA2	−57 −24 43	297	3.54 ( 2.79)
PCC, PCu, R Cu	21 −66 22	1674	−3.36 (−2.69)
L Frontal pole, BA9	−27 51 43	297	−4.00 (−2.68)
Age correlation with EC during CA1 downregulation
R ITG	57 −54 −23	1539	4.62 (3.01)
R ITG	57 −21 −32	837	3.94 (2.83)
L ITG	−63 −45 −20	999	3.38 (2.77)
L ITG	−57 −18 −29	459	2.98 (2.65)
MCC, BA24, BA31	−6 −21 43	1593	−4.10 (−2.94)
R BA40, BA2	57 −24 37	2565	−4.26 (−2.83)
L BA40, BA2	−54 −30 28	675	−3.92 (−2.89)
R Insula, BA13	42 6 −5	297	−3.15 (−2.75)
L Insula, BA13	−36 3 −2	648	−3.35 (−2.60)

The fourth column indicates the maximal z-value of voxels within a cluster (with the mean z-value of all voxels within a cluster in parentheses). CSF amyloid-β₄₂ and p-tau levels were orthogonalized to age, sex, number of APOE ε4 alleles, cognitive reserve, brain reserve and hippocampal downregulation performance. For consistency, CSF amyloid-β₄₂ values were multiplied by −1 during modelling, to align results and colour maps with the direction of the pathophysiological continuum of Alzheimer’s disease. Age was orthogonalized to the CSF p-tau by amyloid-β₄₂ ratio, sex, number of APOE ε4 alleles, cognitive reserve, brain reserve and hippocampal downregulation performance. BA = Brodmann area; Cu = cuneus; L = left; MCC = midcingulate cortex; MNI = Montreal Neurological Institute; NAc = nucleus accumbens; PCC = posterior cingulate cortex; PCu = precuneus; p-tau = phosphorylated tau; R = right.