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. 2020 Feb 3;143(3):771–782. doi: 10.1093/brain/awaa016

Figure 2.

Figure 2

Topology of the human Nav1.7 sodium channel, with the location of I228M, W719C, I739V, L1267V and W1538R. All but one mutation (W719C) are located in the VSDs of the channel. The two lacosamide-responsive mutations are shown in green. Both are located within the vicinity of Domain II: W719C is located at the end of Linker 1 and I739V in VSD II. Non-responsive mutations are indicated in red. All three variants (I228M, L1267V and W1538R) map to the VSD in Domains I, III and IV, respectively.