Figure 3.
Lacosamide effects on voltage-dependence of activation for each Nav1.7 variant. (A) Sodium current traces elicited by the activation protocol from different cells exposed to either lacosamide (LCM) or vehicle control. Sodium inward currents were elicited from a holding potential of −120 mV to various depolarizing steps ranging from −80 to +40 mV in 5 mV increments. (B) Normalized current-voltage relationship obtained by measuring the peak inward current elicited as a function of the stimulus voltage. (C) Voltage-dependence of activation for cells treated with lacosamide or vehicle control. The peak inward currents were transformed to normalized conductance from current-voltage plot.