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. 2020 Feb 3;143(3):771–782. doi: 10.1093/brain/awaa016

Figure 5.

Figure 5

Lacosamide effects on steady state fast inactivation for each Nav1.7 variant. The averaged fast inactivation curves in the presence or absence of lacosamide are shown for (A) wild-type (WT), (B) I228M, (C) W719C, (D) I739V, (E) L1267V and (F) W1538R. The average V1/2s calculated from of the Boltzmann fits are listed in Table 1.