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Lacosamide effects on use-dependent block for each Nav1.7 variant. The averaged use-dependent block to a train of 20 pulses at 20 Hz in the presence or absence of lacosamide are shown for (A) wild-type (WT), (B) I228M, (C) W719C, (D) I739V, (E) L1267V and (F) W1538R. The averages of the normalized responses are shown in Table 1.
