Figure 5.
Association between CSF sTREM2 and CSF amyloid-β and tau biomarkers. Significant association was observed between CSF sTREM2 levels and CSF total tau (A–C) and p-Tau181 (D–F) for all diagnostic groups. In no group did CSF sTREM2 associate with amyloid-β1–42 (G–I). Significant association was observed between CSF sTREM2 levels and CSF amyloid-β1–40 for PD-Normal (J) and PDD diagnoses (L), and trended towards significance in PD-MCI (K). Associations between CSF sTREM2 and biomarkers were assessed using linear mixed-effects model with age and gender as fixed effects and freeze-thaw cycle number as random effect. Biomarker values were log-transformed to reduce skewness. Plotted is the 95% confidence band of the best-fit line from the linear regression. β estimates and P-values from the linear model are shown. Aβ = amyloid-β.