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Hypothetical diagram proposing that at a given level of tau pathology, a minimal TREM2 response could associate with lower CSF sTREM2 and worse cognitive outcomes. Alternatively, a high level of TREM2 response would associate with elevated CSF sTREM2 and better cognitive outcomes. In healthy control participants, baseline TREM2 associates with baseline levels of CSF sTREM2 and stable cognition.
