Table 1.

Criteria for shortening, maintaining, or extending the IVT-AFL injection interval

Criteria for shortening the treatment interval

When any of the following criteria are met for the study eye, the subsequent treatment interval was shortened:     New or persistent fluid with unchanged or increased fluid volume from measurement at the previous treatment visit as indicated by OCT     Loss of ≥ 5 ETDRS letters from the previous visit in conjunction with recurrent fluid on OCT     An increase in CRT of ≥ 100 μm at the central 1 mm compared with the lowest previous value measured by OCT     New-onset neovascularization as determined at the investigator’s discretion based on review of fundus examination and multi-imaging assessment if deemed necessary     New macular hemorrhage     New fluid or persistent intra- or subretinal fluid with unchanged or increased fluid volume from the previous visit as indicated by total OCT scan area (all volumetric fluid assessments were derived from multiple cross-sectional images and extracted from the OCT report)

Criteria for maintaining the treatment interval

If none of the criteria for shortening were met and residual fluid had decreased from the previous visit, then the treatment interval was maintained without change, even with persistent fluid

Criteria for extending the treatment interval

If none of the criteria for shortening were met and there was no fluid on OCT, then the interval was extended

CRT central retinal thickness, ETDRS Early Treatment Diabetic Retinopathy Study, IVT-AFL intravitreal aflibercept, OCT optical coherence tomography