Table 2.
Patient baseline characteristics and demographics (FAS)
| Characteristic | IVT-AFL-2W adjustment | IVT-AFL-4W adjustment | Total |
|---|---|---|---|
| n = 123 | n = 123 | N = 246 | |
| Age, mean (SD), years | 73.0 (7.9) | 75.0 (8.1) | 74.0 (8.0) |
| Sex, n (%) | |||
| Male | 87 (70.7) | 91 (74.0) | 178 (72.4) |
| Baseline BCVA score, mean (SD) | 54.8 (13.1) | 55.3 (12.0) | 55.0 (12.5) |
| Baseline CRT, mean (SD), µm | 386.2 (159.2) | 370.3 (120.0) | 378.3 (141.0) |
| Type of exudative AMD, n (%)a | |||
| Typical AMD | 75 (61.0) | 75 (61.0) | 150 (61.0) |
| Polypoidal choroidal vasculopathy | 46 (37.4) | 44 (35.8) | 90 (36.6) |
| Retinal angiomatous proliferation | 4 (3.3) | 9 (7.3) | 13 (5.3) |
| Type of CNV lesions on FA, n (%)b | |||
| Classic CNV | 35 (28.5) | 42 (34.1) | 77 (31.3) |
| Classic CNV and occult CNV | 14 (11.4) | 17 (13.8) | 31 (12.6) |
| Occult CNV | 72 (58.5) | 62 (50.4) | 134 (54.5) |
| Pigment epithelial detachment, n (%) | 83 (67.5) | 78 (63.4) | 161 (65.4) |
| Subretinal fluid, n (%) | 104 (84.6) | 104 (84.6) | 208 (84.6) |
| Intraretinal fluid, n (%) | 43 (35.0) | 44 (35.8) | 87 (35.4) |
| Hemorrhage, n (%) | 67 (54.5) | 61 (49.6) | 128 (52.0) |
| Subretinal hemorrhage | 56 (45.5) | 50 (40.7) | 106 (43.1) |
| Intraretinal hemorrhage | 28 (22.8) | 30 (24.4) | 58 (23.6) |
2W/4W 2-/4-week adjustment, AMD age-related macular degeneration, BCVA best-corrected visual acuity, CNV choroidal neovascularization, CRT central retinal thickness, FA fluorescein angiography, FAS full analysis set, IVT-AFL intravitreal aflibercept, SD standard deviation
aPatients could be classified into more than one group
bUnknown in the IVT-AFL-2W (n = 2) and IVT-AFL-4W (n = 1) adjustment groups and one patient had no CNV in the IVT-AFL-4W group