Why carry out this study?

The goal of proactive flexible treat-and-extend (T&E) regimens is to reduce the treatment burden associated with anti-vascular endothelial growth factor (VEGF) therapy, while maintaining a patient’s visual acuity gains.

The aim of this study was to evaluate the efficacy and safety of intravitreal aflibercept (IVT-AFL) T&E dosing regimens in treatment-naïve patients with exudative age-related macular degeneration (AMD).

What was learned from the study?

IVT-AFL administered using either 2- or 4-week adjustment T&E regimens in treatment-naïve patients with exudative AMD improved functional (best-corrected visual acuity + 9.0 and + 8.4 letters) and anatomic outcomes (central retinal thickness − 134.4 and − 126.1 µm) at 52 weeks; functional and anatomic outcomes were maintained over 96 weeks.

A large proportion of patients (35.1% and 40.5%) had an intended injection interval of 16 weeks at week 52.

The incidence of treatment-emergent adverse events was consistent with the known safety profile of IVT-AFL.

IVT-AFL T&E regimens were efficacious and safe over 96 weeks of treatment using either 2- or 4-week adjustments.